Recombinetics Swine Models and Custom Models

Recombinetics has years of experience creating swine models of human diseases for biomedical research. We have built a platform using advanced gene editing technologies for precise and efficient creation of disease models for business partners, academic institutions, and internal research projects. We leverage our expertise to offer customizable models in large and minipig breeds. Whether humanizing a gene, multiplexing, or creating multiple somatic cell edits, work with our team to bring an idea from in silico design to animals on the ground.

Gene TherapySwine Reporter Model-1 (SRM-1)Cre or CRISPR activated tdTomato
Swine Reporter Model-2 (SRM-2)
ABE activated GFP and tdTomato
Cancer and Rare Disease
Neurofibromatosis type 1 (NF1)
Heterozygous inactivation of NF1
Neurofibromatosis type 2 (NF2)
Heterozygous inactivation of NF1
GlioblastomaInduced w/ human mutations
Hepatocellular carcinomaInduced w/ human mutations
Microvillus Inclusion DiseaseMYO5B-P660L
CardiovascularHypercholesterolemiaPCSK9D374Y and LDLR-/- Ossabaw swine
Dilated cardiomyopathy (DCM)RBM20R636S Homozygous or Heterozygous
DiabetesMetabolic Syndrome/Obesity
Ossabaw swine on western diet
Metabolic Syndrome with AtherosclerosisHypercholesterolemic Ossabaw swine on western diet
HepaticAlpha-1 antitrypsin deficiency
Ossabaw swine with PiZ allele
PhenylketonuriaInactivating mutations in PKU
ImmunologyImmunodeficiencyRAG2/IL2Rg KO
RenalAutosomal dominant polycystic kidney disease (ADPKD)
Inducible PKD1 inactivation
Autosomal recessive polycystic kidney disease (ARPKD)PKHD1 inactivating mutations including T36M
Skeletal Osteogenesis Imperfecta

Recombinetics Swine Reporter Model (SRM1)

The SRM1 is the first large animal model designed to track gene editing in any tissue or cell in the body. This unprecedented large animal model was engineered by harboring a genetic reporter in every cell that can only be activated by gene editors like CRISPR or by Cre recombinase. Fluorescent markers are used to track gene delivery in any tissue or cell in as little as one week extending to months or years even with non-viral vectors.