about our technology
Unlocking the Power of the Genome
The prospect of preventing and curing disease, feeding a hungry planet and improving the health, longevity and livelihood of every person on the planet is thrilling, yet daunting.
Through gene editing (or genome editing), Recombinetics scientists improve the genetics of animals by making precise changes to their DNA that unlock new traits. Our team of experts tirelessly and responsibly apply the science so we can realize this incredible potential.
In animal agriculture, we leverage natural variation in animal breeds to discover high impact variants that can only be deployed effectively by gene editing.
In biomedical and regenerative medicine, our ability to introduce changes in animal DNA opens vast new opportunities to improve and extend human life through novel products and improved translation of cell and gene therapies to patients.
tools
Putting Our Knowledge to Work
Numerous technological advances over the last decade make it possible to modify animal genomes accurately and efficiently.
Recombinetics has developed the knowledge to develop and deploy a multitude of gene editing tools, including TALENs and CRISPRs, to help us intentionally cut the genetic code in the proper place and harness the cell’s DNA repair machinery to introduce the desired change in livestock and fish.
regulation
Ensuring Safe & Humane Treatment
Gene editing outcomes are tested at various stages along its development cycle from the first introduction into laboratory cells to the production of the animal.
Our research is overseen by a variety of governmental agencies, including the FDA and USDA, as well as non-governmental agencies to ensure our compliance with all state and federal/national policies, guidelines and industry best practices.
When working with international partners, we honor the laws and regulations of all countries where we do business. We take extraordinary measures to ensure the safe and humane treatment of the animals with which we work.
applications
Gene Editing in Biomedicine
Gene editing in biomedicine allows for more advanced animal models for studying human diseases and for testing and developing safer and more effective therapeutics.
Recombinetics deploys gene editing through our BioVentures and core products and services:
Sarxion Biologics is engineering materials for regenerative medicine. The company is initally focused on Hernia repair. Sarxion Biologics’ ECM material has improved integration and healing.
Therillume is a clinical-stage neuro-oncology therapeutics company bringing precision medicine to patients with Glioblastoma (GBM) and Neurofibromatosis Types 1 and 2 (NF1 and NF2).
Recombinetics – core products and services
- Preclinical Services – Recombinetics offers genome editing, veterinary oversight, scientific expertise, and novel swine models to execute integral pre-clinical studies that accelerate scientific discovery. From pharmacokinetic and pharmacodynamic testing, surgical interventions and delivery, to unique model development, Recombinetics takes an innovative approach to running pre-clinical studies that can cover all aspects from in vitro to in vivo studies and beyond.
- Swine Reporter Models track the delivery of viral or nonviral gene editing therapeutics, the first large animal models of its kind. These models allow researchers to test both new delivery modalities and explore new routes of administration, both using a highly translational animal model for patient care.
- Gene Editing Services – Recombinetics specializes in gene editing for agricultural and biomedical applications. Utilizing cutting edge genome technologies, paired with stringent quality assurance and quality control measures, Recombinetics delivers revolutionary gene-edited products of the highest quality.
applications
Gene Editing in Agriculture
Gene editing used in food animals enables improved animal welfare, lessened use of antibiotics and improved environmental stewardship through lower greenhouse gas outputs and decreased use of natural resources.
Recombinetics deploys gene editing in agriculture and aquaculture through its subsidiary Acceligen.
