Recombinetics Swine Models and Custom Models

Recombinetics has years of experience creating swine models of human diseases for biomedical research. We have built a platform using advanced gene editing technologies for precise and efficient creation of disease models for business partners, academic institutions, and internal research projects. We leverage our expertise to offer customizable models in large and minipig breeds. Whether humanizing a gene, multiplexing, or creating multiple somatic cell edits, work with our team to bring an idea from in silico design to animals on the ground.

IndicationModel*Description
Gene TherapySwine Reporter Model-1 (SRM-1)Cre or CRISPR activated tdTomato
Swine Reporter Model-2 (SRM-2)
Base Editor and Prime Editor activated tdTomato
Cancer and Rare Disease
Neurofibromatosis type 1 (NF1)
Heterozygous inactivation of NF1
Neurofibromatosis type 2 (NF2)
Heterozygous inactivation of NF2
GlioblastomaInduced w/ human mutations
Hepatocellular carcinomaInduced w/ human mutations
Microvillus Inclusion DiseaseMYO5B-P660L
CardiovascularHypercholesterolemiaPCSK9-D374Y and LDLR-/- Ossabaw swine
Dilated cardiomyopathy (DCM)RBM20-R636S Homozygous or Heterozygous
DiabetesMetabolic Syndrome/Obesity
Ossabaw swine on western diet
Metabolic Syndrome with AtherosclerosisHypercholesterolemic Ossabaw swine on western diet
HepaticAlpha-1 antitrypsin deficiency
PiZ allele
PhenylketonuriaInactivating mutations in PKU
ImmunologyImmunodeficiencyRAG2/IL2Rg KO
RenalAutosomal dominant polycystic kidney disease (ADPKD)
Inducible PKD1 inactivation
Autosomal recessive polycystic kidney disease (ARPKD)PKHD1 inactivating mutations including T36M
SkeletalOsteogenesis Imperfecta
COL1A1-R235X
Custom ModelingSwine Breeds AvailableDescription
Yucatan (Mini-pig)Partner for custom pig models
Large White
Ossabaw

*Swine Model Tissues Available upon request

Recombinetics Swine Reporter Models

The Swine Reporter Models (SRM-1 and SRM-2) are large animal models designed to track gene delivery to any tissue or cell in the body. Fluorescent markers are activated by gene editing in as little as one week, extending to months or years even with non-viral vectors.