We’re in Baltimore for ASGCT 2024! Stop by poster #517 on Wednesday, May 8th at 5:30 EST to hear from Jarryd Campbell about our swine reporter models for somatic cell genome editing. We are looking forward to making some new connections and meeting up with old colleagues.
Spermatogonial stem cell (SSC) transplantation into the testis of a germ cell (GC)-depleted surrogate allows transmission of donor genotype via donor-derived sperm produced by the recipient. Transplantation of gene-edited SSCs provides an approach to propagate gene-edited large animal models. DAZL is a conserved RNA-binding protein important for GC development, and DAZL knockout [...]
CD163 expressed on cell surface of porcine alveolar macrophages (PAMs) serves as a cellular entry receptor for porcine reproductive and respiratory syndrome virus (PRRSV). The extracellular portion of CD163 contains nine scavenger receptor cysteine-rich (SRCR) and two proline-serine-threonine (PST) domains. Genomic editing of pigs to remove the entire CD163 or [...]
The term ‘Criollo’, with origins in the Portuguese ‘Crioulo’, historically distinguished people born in the New World from those native to Iberia and was subsequently extended to livestock (cattle, sheep, horses and goats).
Representing Acceligen, I was connecting with collaborators and experts in policy and communication at the Africa Biennial Biosciences Communication (ABBC 2023) Symposium. The theme of this important event - “Evolution of Genetic Improvement Tools in Agriculture: Is communication matching up?” has addressed key issues facing developers, policymakers, and investors bringing [...]
Acceligen values education and extension activities to inform stakeholders and consumers about its breeding technologies focused on well-being, health, and sustainability for animal agriculture.
A winning solution to KidneyX’s inaugural prize competition, the Artificial Kidney Prize – Phase 1, came from Makana Therapeutics. This submission is titled, “Xenotransplantation: A treatment for Kidney Failure.”
EAGAN, Minn., Sept. 15, 2021 /PRNewswire/ -- Makana Therapeutics today received a $650,000 KidneyX Artificial Kidney Prize for their work to increase the supply of kidney donor organs through pig-to-human xenotransplants. Xenotransplantation is the process of transplanting organs or tissues between members of different species into humans, thus addressing the [...]
The FDA greenlights α-Gal allergy-safe meat, but its makers have organs for transplants in their sights. The first genetically engineered pig products could soon be coming to a dinner plate—or pharmacy—near you. Late last year, the US Food and Drug Administration (FDA) authorizeda facility in northern Iowa to raise hogs [...]
Recombinetics Inc., a leading gene editing company with platform technology applied to biomedicine and animal agriculture, today announced a first-of-its-kind study to improve outcomes for patients diagnosed with a rare disease known as Tuberous Sclerosis Complex (TSC). Surrogen, a subsidiary of Recombinetics Inc., is focused on developing large animal models [...]