our publications
About Animal welfare and Disease Resistance
Genetically modified pigs lacking CD163 PSTII-domain-coding exon 13 are completely resistant to PRRSV infection.
Published in Antiviral Research
First gene-edited calf with reduced susceptibility to a major viral pathogen.
Published in PNAS Nexus
CRISPR/Cas9-editing of KISS1 to generate pigs with hypogonadotropic hypogonadism as a castration free trait.
Published in Fronter Genetics
Evaluating Large Spontaneous Deletions in a Bovine Cell Line Selected for Bovine Viral Diarrhea Virus Resistance.
Published in Viruses
Three novel nonsense mutations of prolactin receptor found in heat-tolerant Bos taurus breeds of the Caribbean Basin.
Published in Animal Genetics
Production of hornless dairy cattle from genome-edited cell lines.
Published in Nature Biotechnology
About Gene Editing
In vivo genome editing using a high-efficiency TALEN system
Published in Nature
Efficient TALEN-mediated gene knockout in livestock.
Published in Proceedings of the National Academy of Sciences
Efficient nonmeiotic allele introgression in livestock using custom endonucleases.
Published in Proceedings of National of the National Academy of Sciences
TALEN-mediated gene targeting in porcine spermatogonia.
Published in Molecular Reproduction and Development
Targeted Gene Editing in Porcine Spermatogonia.
Published in Frontiers in Genetics
Simple and efficient methods for enrichment and isolation of endonuclease modified cells.
Published in PLOS One
About Cardiovascular Disease
Dysregulated ribonucleoprotein granules promote cardiomyopathy in RBM20 gene-edited pigs.
Published in Nature Medicine
Ossabaw Pigs With a PCSK9 Gain-of-Function Mutation Develop Accelerated Coronary Atherosclerotic Lesions: A Novel Model for Preclinical Studies.
Published in Journal of American Heart Association
Peripheral vascular atherosclerosis in a novel PCSK9 gain-of-function mutant Ossabaw miniature pig model
Published in Translational Research
about cancer
Engineered swine models of cancer
Published in Frontiers in Genetics
Combining nonsense mutation suppression therapy with nonsense-mediated decay inhibition in neurofibromatosis type 1.
Published in Molecular Therapy. Nucleic Acids
Selumetinib normalizes Ras/MAPK signaling in clinically relevant neurofibromatosis type 1 minipig tissues in vivo.
Published in Neuro-Oncology
Genetically engineered minipigs model the major clinical features of human neurofibromatosis type 1.
Published in Nature’s Communication Biology
media attention
Our work has been featured in the following national, international and industry media outlets:
