Publications – Recombinetics

our publications

About Animal welfare and Disease Resistance

Genetically modified pigs lacking CD163 PSTII-domain-coding exon 13 are completely resistant to PRRSV infection.

Published in Antiviral Research

First gene-edited calf with reduced susceptibility to a major viral pathogen.

Published in PNAS Nexus

CRISPR/Cas9-editing of KISS1 to generate pigs with hypogonadotropic hypogonadism as a castration free trait.

Published in Fronter Genetics

Evaluating Large Spontaneous Deletions in a Bovine Cell Line Selected for Bovine Viral Diarrhea Virus Resistance.

Published in Viruses

Three novel nonsense mutations of prolactin receptor found in heat-tolerant Bos taurus breeds of the Caribbean Basin.

Published in Animal Genetics

Production of hornless dairy cattle from genome-edited cell lines.

Published in Nature Biotechnology

About Gene Editing

In vivo genome editing using a high-efficiency TALEN system

Published in Nature

Efficient TALEN-mediated gene knockout in livestock.

Published in Proceedings of the National Academy of Sciences

Efficient nonmeiotic allele introgression in livestock using custom endonucleases.

Published in Proceedings of National of the National Academy of Sciences

TALEN-mediated gene targeting in porcine spermatogonia.

Published in Molecular Reproduction and Development

Targeted Gene Editing in Porcine Spermatogonia.

Published in Frontiers in Genetics

Simple and efficient methods for enrichment and isolation of endonuclease modified cells.

Published in PLOS One

About Cardiovascular Disease

Dysregulated ribonucleoprotein granules promote cardiomyopathy in RBM20 gene-edited pigs.

Published in Nature Medicine

Ossabaw Pigs With a PCSK9 Gain-of-Function Mutation Develop Accelerated Coronary Atherosclerotic Lesions: A Novel Model for Preclinical Studies.

Published in Journal of American Heart Association

Peripheral vascular atherosclerosis in a novel PCSK9 gain-of-function mutant Ossabaw miniature pig model

Published in Translational Research

about cancer

Engineered swine models of cancer

Published in Frontiers in Genetics

Combining nonsense mutation suppression therapy with nonsense-mediated decay inhibition in neurofibromatosis type 1.

Published in Molecular Therapy. Nucleic Acids

Selumetinib normalizes Ras/MAPK signaling in clinically relevant neurofibromatosis type 1 minipig tissues in vivo.

Published in Neuro-Oncology

Genetically engineered minipigs model the major clinical features of human neurofibromatosis type 1.

Published in Nature’s Communication Biology

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