Delivering Biomedical Models for Developing Human Therapeutics

The demand for patient cures is great. Unfortunately, the cost of bringing a new drug to the clinic is staggering (approximately $1B) and the time required to obtain FDA approval is prohibitively long (approximately 10 years). Consequently, there is considerable interest in improving strategies to predict the safety and efficacy of new drugs, devices, and protocols while speeding up their development.

Surrogen provides solutions to find patient cures faster by gene editing pigs with human diseases. Surrogen pigs enable a more thorough examination of the onset and progression of human disease, and the safety and efficacy of therapeutics designed to arrest it.

Surrogen’s Pig Models of Human Disease 

When compared to traditional animal disease models, Surrogen’s gene edited pigs offer better quality data, improved decision making, decreased product development time, and ultimately a lower R&D costs to the drug and device industries. In addition, Surrogen’s gene-edited models have the ability to show comorbidity environments that more closely resemble real-world disease states.

Surrogen is developing humanized swine models of these categories of diseases:

  • Cancer
  • Cardiovascular Diseases
  • Congenital Conditions
  • Hereditary & Neonatal Diseases
  • Diabetes/Metabolic Syndrome
  • Neurodegenerative Diseases

 

 

 

 

Surrogen Pigs Provide:

  • Increased speed-to-market,
  • Lower research costs,
  • Reduced failure rates,
  • Customizable options,
  • Means to evaluate diseases with small patient populations,
  • Ways to examine interventions systemically, and
  • Opportunities to make better products.

The Pig Model Advantage

Surrogen’s gene-edited swine provide an unrivaled advantaged over traditional animal models. Swine are and/or have:

  • The pig is one of the closest non-primate species to humans,
  • Organ systems highly similar to humans,
  • Advanced cognitive abilities,
  • Well-established for the use in preclinical research,
  • Well-established for use of skin and heart valves in the clinic, and
  • Fast gestation period (three months, three weeks, three days).

The Genome Editing Advantage

Scientists have identified more than 10,000 single gene mutations that play roles in diseases and medical conditions. Surrogen leverages its world-leading expertise in the use of gene-editing tools like transcription activator-like effector nucleases (TALENs), clustered regularly interspaced short palindromic repeats (CRISPR/Cas9) and others to design optimized swine models for a wide array of disease-causing mutations identical to those in human patients. Thus, we are creating disease models in swine that are genetically identical and highly similar to humans.

 

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Contact Us

To learn more about Surrogen, call 612-727-2000 or email info@recombinetics.com.

The Swine Model Advantage

Surrogen’s gene-edited swine provide an unrivaled advantaged over traditional animal models. Swine are and/or have:

  • The pig is one of the closest non-primate species to humans,
  • Organ systems highly similar to humans,
  • Advanced cognitive abilities,
  • Well-established for the use in preclinical research,
  • Well-established for use of skin and heart valves in the clinic, and
  • Fast gestation period (three months, three weeks, three days).