Leveraging a Preeminent R&D Platform to Develop and Commercialize Products Across Key Markets

RCI is far outpacing its competitors in intellectual property and practical applications and addressing the human health and animal agriculture markets. As a recognized leader in gene editing in large animal models, RCI’s global patent portfolio includes 25 issued patents, more than 300 additional applications filed, including first use and enabling patent claims for livestock (including, but not limited to both CRISPR and TALENs).

RCI’s leadership team, board of directors, and distinguished scientific advisory board include many of the world’s leading genetics experts – complemented by world-class executives with a track record of success.

Key accomplishments include:

2018

Biomedicine Highlights
Agriculture Highlights
Core Technology Platform Highlights
  • Collaboration with Mayo Clinic announced to develop cardiomyocytes
  • Alliance to end castration of swine announced with collaborators in the United States and the Netherlands
  • Alliance to end dehorning of cattle announced with collaborators in Canada; first commercial deal for polled genetics
  • First gene edited thermotolerant cattle born
  • Brazil authorities concluded gene-edited dehorned cattle aren’t GMOs
  • Target TB announced with collaborators in Ireland and Northern Ireland to curb tuberculosis in cattle

2017

Biomedicine Highlights
Agriculture Highlights
Core Technology Platform Highlights
  • First patent issued in China for gene editing large animals
  • First patent issued in Europe for gene editing large animals
  • Collaboration with Mayo Clinic announced to pig model of congenital heart failure
  • Collaboration with Children’s Minnesota announced to develop pig model of phenylketonuria
  • Announcement of major developments in neurofibromatosis Type 1 model funded by Children’s Tumor Foundation
  • First gene edited poultry birds produced in Europe
  • First genetically dehorned heifer born

2016-2008

Biomedicine Highlights
Agriculture Highlights
Core Technology Platform Highlights
  • First pig model of congenital heart failure developed
  • First pig model of polycystic kidney diseases developed
  • First-of-its-kind pig model of Neurofibromatosis Type 1 developed
  • First utility patent filed in the US for methods for producing transgenic pigs
  • First to make APOBEC pigs for PERV-safe organs
  • First DNA transposon engineered pig born
  • First genetically dehorned cattle born
  • First to gene-edit for accelerated reproduction OPU in cattle
  • First patent issued in the US for CRISPR gene editing in animals optimized to prevent re-cutting of the target sequence
  • First to achieve multi-gene editing in pigs and cattle
  • First to enable CRISPR in large animals
  • First filed CRISPR utility patents in large animals
  • First to transfer native allele in species
  • First TALENS use to knockout & break genes in embryos