Founded in 2008, Recombinetics is a privately held biotechnology company that aims at helping to solve some of the world’s most intractable challenges through gene editing. Recombinetics is delivering viable products and generating revenues today from the large and growing biomedical and agricultural markets.
Recombinetics focused its early stage development on the application of precision genetic technologies and active patent filings in animals. Development of advanced “gene-editing” technologies for commercial purposes began in 2011. Today, Recombinetics is widely recognized as the leader in livestock gene-editing and associated applied technologies for biomedical research, regenerative medicine, and animal agriculture.
Recombinetics’ first gene-edited animals are generating revenues today with a pipeline of animals under development for the large biomedical and agricultural markets.
With a robust intellectual property portfolio, RCI leverages its research platform to commercialize and deploy its invented and licensed technologies across key markets.
RCI’s growing global patent portfolio includes 25 issued patents, more than 300 additional applications filed, and first use and enabling patents for livestock for both CRISPR and TALENs. Here are some of RCI’s achievements in science.
Some key business highlights include:
Our scientific findings are often published in peer-reviewed scientific journals and often cited by other scientists in their published research. Our work has been documented in over 300 peer-reviewed publications and written been covered many times by both scientific and consumer media outlets. Here are some of our recent publications:
Genetically engineered minipigs model the major clinical features of human neurofibromatosis type 1 Published in Nature’s Communication Biology
A new tool for mapping breast cancer risk in the tumor microenvironment Published in Cancer Research
About cardiovascular disease
Peripheral vascular atherosclerosis in a novel PCSK9 gain-of-function mutant Ossabaw miniature pig model Published in Translational Research
About gene editing and advanced reproduction of pigs
In vivo genome editing using a high-efficiency TALEN system Published in Nature
Precision editing of large animal genomes Published in Advances in Genetics
Efficient TALEN-mediated gene knockout in livestock Published in Proceedings of the National Academy of Sciences
Precise genome editing of PDX1 by direct injection of transcription activator-like effector nucleases (TALENS) into Parthenogenetic Pig Embryos Published in Reproduction, Fertility and Development
Efficient Nonmeiotic Allele Introgression in Livestock Using Custom EndonucleasesPublished in Proceedings of National of the National Academy of Sciences
Editing Livestock Genomes with Site-Specific Nucleases Published in the Journal of Reproduction, Fertility and Development
Live pigs produced from genome edited zygotes Published in Scientific Reports
TALEN-mediated gene targeting in porcine spermatogonia Published in Molecular Reproduction and Development
Simple and efficient methods for enrichment and isolation of endonuclease modified cells Published in PLOS One
Our science is often covered by the media helping to educate the public on gene editing. Here are some of our media highlights:
Check out other media stories in our online Newsroom.